Question:

Gaylen –         The dose for MS er’s is 10x your cholestorol lowering dose. I don’t know what happens to you if your cholesterol goes TOO low. – Hide quoted text — Show quoted text ->I’ve been taking Lipitor for  over a year, for cholesterol, and at that >dosage I see NO affect on MS. >Gaylan

Response:

<d…@cheetah.net> wrote in message

news:[email protected]… > On Wed, 27 Nov 2002 22:04:30 -0400, "Gaylan" <gay…@attcanada.net> wrote: > >I’ve been taking Lipitor for  over a year, for cholesterol, and at that > >dosage I see NO affect on MS. > >Gaylan > Gaylan, has Lipitor significantly reduced > the cholesterol? > Donn

Yes, it has.  It is within normal/regular/healty levels. And that is with eating some cholesterol foods, too.  Although I do watch my diet, eat no red meat, and consumption of animal products like cheese, ice cream, is way down. Gaylan

Response:

What concerns me about the increased dosage for MS is what will it do to your liver? Gaylan "Charles Douglas" <not.chdouglas.nomores…@not.attbi.com> wrote in message

news:[email protected]… – Hide quoted text — Show quoted text -> Gaylen – > The dose for MS er’s is 10x your cholestorol lowering dose. I > don’t know what happens to you if your cholesterol goes TOO low. > >I’ve been taking Lipitor for  over a year, for cholesterol, and at that > >dosage I see NO affect on MS. > >Gaylan

Response:

- Hide quoted text — Show quoted text -On Fri, 29 Nov 2002 12:05:36 -0400, "Gaylan" <gay…@attcanada.net> wrote: ><d…@cheetah.net> wrote in message >news:[email protected]… >> On Wed, 27 Nov 2002 22:04:30 -0400, "Gaylan" <gay…@attcanada.net> wrote: >> >I’ve been taking Lipitor for  over a year, for cholesterol, and at that >> >dosage I see NO affect on MS. >> >Gaylan >> Gaylan, has Lipitor significantly reduced >> the cholesterol? >> Donn >Yes, it has.  It is within normal/regular/healty levels. And that is with >eating some cholesterol foods, too.  Although I do watch my diet, eat no red >meat, and consumption of animal products like cheese, ice cream, is way >down. >Gaylan

Great!!! DCI

Response:

Diane Komaroff wrote: > Did anybody just see CNN? > They had a report on the anti-colesterol drug, called Lipitor. > They have seen positive results with iddy biddy mice; of course, they have had > to use ten times the amount used on a human for colesterol. > They found it has been excellent on the mice, and are planning on testing it on > us. > If it helps, they said it wouldn’t take as long with the danger testing > as it has already been passed here for colesterol > Soooooooooooooo???????????????

I’ve seen that reported somewhere before … I noted it because my best friend takes Lipitor for cholesterol … for some reason, Reuters reported it back in May.

Response:

On Wed, 06 Nov 2002 23:58:38 GMT, KKT <adfa…@adfa.com> wrote in alt.support.mult-sclerosis: >I’ve seen that reported somewhere before … I noted it because my >best friend takes Lipitor for cholesterol … for some reason, >Reuters reported it back in May.

I guess CNN is having a slow news day.  :-) — From: doe (ironjust…@aol.comdoe) Newsgroup: Sci.med  Date: 2002-10-13 18:14:20 PST [snip] That would make you even more clueless than me .. or can’t you understand that

Response:

It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, who could tell us right now if the lipitor has any affect on their MS symptoms… "Jim Carter" <spam.f…@softhome.net> wrote in message

news:[email protected]… – Hide quoted text — Show quoted text -> On 6 Nov 2002 15:35:01 -0800, dianekkomar…@msn.com (Diane Komaroff) wrote in > alt.support.mult-sclerosis: > >Did anybody just see CNN? > >They had a report on the anti-colesterol drug, called Lipitor. > >They have seen positive results with iddy biddy mice; of course, they have had > >to use ten times the amount used on a human for colesterol. > >They found it has been excellent on the mice, and are planning on testing it on > >us. > >If it helps, they said it wouldn’t take as long with the danger testing > >as it has already been passed here for colesterol > >Soooooooooooooo??????????????? > >Diane > I have been watching this for some time.  Here is an article from last April > about one of the anti-cholesterol drugs, but if we were mice then we would have > been cured long ago. > =============================================================== > A commonly used cholesterol lowering drug has been used to reverse the symptom > of multiple sclerosis in lab experiments on mice. > The statin drug atorvastatin is prescribed for patients at risk of heart disease > because it reduces the levels of potentially harmful cholesterol in the blood. > However, it also has the ability to influence the immune system. > In lab tests it was effective at reversing paralysis in mice with MS-type > symptoms. > The research was carried out by a team from Stanford University in the US. > MS is caused by the immune system turning in on itself and attacking the body’s > own central nervous system. > This results in the progressive destruction of myelin – the tissue that sheathes > and protects the nerves. > Without myelin, the nerves cease to function properly, and patients gradually > lose the ability to move normally. Eventually they become paralysed. > Related condition > The researchers worked on mice which had a similar condition to MS. > In this condition the myelin destruction is caused by specialised immune system > cells called T lymphocytes. > These cells produce too many cytokines – chemicals which inflame the nervous > system and stimulate myelin damage. > The researchers found that the statin drug significantly reduced inflammation. > Not only did the drug reduce the secretion of cytokines that cause inflammation, > it stimulated production of another type of cytokine that has the opposite > effect. > The researchers believe that statins may also be useful at treating other > autoimmune diseases such as insulin-dependent diabetes and rheumatoid arthritis. > ‘Encouraging’ > Professor John Greenwood, of University College London, who is funded by the MS > Society, said the drugs had been shown to have a multiple effect on the immune > system. > He has worked closely with scientists from the Institute of Ophthalmology. > He told BBC News Online: "Interestingly, a study conducted by us using a > different class of inhibitors, which are able to inhibit some of the same target > molecules as statins, have also been shown to limit brain inflammation." > Christine Jones, chief executive of the MS Trust, said: "Of course these are > very early findings but it may be that this experimental work will prove useful > in terms of therapy for MS. > "Particularly encouraging, according to reported findings, is that this > treatment, based on a cholesterol lowering agent, actually reverses symptoms." > Professor Greenwood’s research is one of three studies into the how immune cells > enter the brain and attack the myelin coating which are being funded by the MS > Society. > — > From: watchman (watch…@nucleus.com) > [Now ironjust...@aol.com] > Newsgroups: alt.support.thyroid > Date: 2002-01-12 15:56:30 PST > "Look lady .. if you don’t know what you are talking about ‘medically’ .. > then stay out of it .. The man has had three miscarriages/spontaneous > abortions."

Response:

On Wed, 27 Nov 2002 22:04:30 -0400, "Gaylan" <gay…@attcanada.net> wrote: >I’ve been taking Lipitor for  over a year, for cholesterol, and at that >dosage I see NO affect on MS. >Gaylan

Gaylan, has Lipitor significantly reduced the cholesterol? Donn

Response:

On 11/27/02 3:40 AM, in article 7q49uu0ksf8l8qe9i3mj8q0grmn645d…@4ax.com, "James" <tuningoutNOS…@yahoo.ca> wrote: > That’s great to hear. I have a couple questions: > -How did you get the perscription? Did your doctor endorse this? > -Are there any side effects? > -What’s the cost like? > Either way, keep us posted with how it’s going. > -James K

Well, first of all, I was prepared to see the doctor by getting as much information as I could about Lipitor and MS from the internet. Much of the stuff was of a technical nature and was info that he could relate to. Over the years, I’ve established a good relationship with my physician where I would find out about a new treatment, do the research on the net, take the info to him and he would take action. However, this is really the first medicine I’ve taken since I’ve been diagnosed that has had any significant impact on me at all. Let me tell you what happened on Tuesday night: Lying in bed, I remembered some of my medical training (I’m a Physical Therapy Assistant) how vitamin B complex would help to promote a healthy nervous system so, about 9 that night, I took a tablet. About an hour later, while lying in the bed, I was feeling much lessening of the inflammation, which, I attributed to the B vitamin I had just taken. Plus, I felt that the tonal problems I usually have were much less than usual. So, I attempted to bend the left leg at the knee, which, usually is a very difficult maneuver for me because of the tonal problems and limited strength in that extremity. Not to hard to do. Hmm Now to extend the leg. Usually when I do this, both muscle groups in the upper part of my leg (quadriceps/hamstrings) will contract at the same time making for a very stiff movement. After the leg is extended, it would take about 10 seconds or so for the muscles to relax. This time, the tone was much reduced making for a much more normal movement. Spasticity, I feel, can mask whatever strength you have as both muscle groups are co-contracting making movement doubly difficult. I was starting to get a little bit excited. Next were some bed mobility things such as rolling to my side, which, recently, has become almost impossible to do. I rolled over to my right side with minimal effort, and assumed my favorite position which is to bring the knee up a bit. Whoa! I did it several more times just to make sure I wasn’t dreaming. By this time it was around 10 at night, but I had to take the next step which was a sit to stand transfer from the bed. Lately, transfers such as this had become quite labored. The legs were doing little of the work, and I would have to use my hands, placed on an object in front of me, so that they could do most of the work, pulling me up to a standing position. So I assumed the proper position, scooted to the edge of the bed, feet behind the knees, leaned forward, placed my hands on the bed (not in from of me on the walker), and, with little effort, stood. Wow! I did it several times more because I couldn’t believe how easy it was to do. The hands were doing very little of the work and the legs were exerting most of the force needed to do this motion. At this point, I was so excited, I stayed up until after midnight, as I couldn’t sleep. I’ve had several days like this where I’ve noticed various functional improvements which translated to increased capability in various areas. However, the next day, I woke up and the tone was slightly worse (as it is most mornings), but continued to improve as the day went on (usually in the evening. You asked about side effects. Mainly there is a slight risk of liver damage on this med, but that’s about it. Cost, well, I’m not sure as I have health insurance that pays for the bulk of it after a co-pay each time I get the script refilled. But, in my opinion, it’s well worth it. We’ll see what happens in the months to come. I’ll periodically post back to this forum with details from time to time. Bye for now.

Response:

Does anyone know whether Lipitor works in a similar way to Baycol ?

Response:

> Does anyone know whether Lipitor works in a similar way to Baycol ?

Chemical description of both products follow. A trial is scheduled for another statin: Zocor and the chemical description for that has been included as well. Baycol is not available in the US, so that may account for it’s exclusion from the trials there. wiredbeard ——————————————— Lipitor: Atorvastatin calcium is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3 hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. Atorvastatin calcium is [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4 [(phenylamino)carbonyl]-lH-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate. The empirical formula of atorvastatin calcium is (C33H34FN2O5)2Ca.3H2O and its molecular weight is 1209.42. Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile, slightly soluble in ethanol, and freely soluble in methanol. Lipitor tablets for oral administration contain 10, 20, or 40 mg atorvastatin and the following inactive ingredients: calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF; lactose monohydrate, NF; magnesium stearate, NF; microcrystalline cellulose; NF, Opadry White YS-1-7040 (hydroxypropylmethylcellulose, polyethylene glycol, talc, titanium dioxide); polysorbate 80, NF; simethicone emulsion. Baycol: Cerivastatin sodium is sodium [S-[ R*, S'-( E)] -7-[ 4-( 4-b fluorophenyl)-5-methoxymethyl)- 2,6bis( l-met ylethyl) 3-pyridinyll-3,5-dihydroxy+ heptenoate. The empirical formula for cerivastatin sodium is C26 H 33FN05Na and its molecular weight is 481.5. Cerivastatin sodium is a white to off-white hygroscopic amorphous powder that is soluble in water, methanol, and ethanol, and very slightly soluble in acetone. Cerivastatin sodium is an entirety synthetic, enantiomeritally pure inhibitor of 3-hydroxy-3- methylglutatyl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol. BAYCOL (cerivastatin sodium tablets) is supplied as tablets containing 0.2 or 0.4 mg of cerivastatin sodium, for oral administration. Active Ingredient: cerivastatin sodium. Inactive Ingredients: mannitol, magnesium stearate, sodium hydroxide, crospovidone, povidone, iron oxide yellow, methylhydroxypropylcellulose, polyethylene glycol, and titanium dioxide Zocor: Simvastatin is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. After oral ingestion, simvastatin, which is an inactive lactone, is hydrolyzed to the corresponding b-hydroxyacid form. This is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, which is an early and rate-limiting step in the biosynthesis of cholesterol. Simvastatin is butanoic acid, 2,2-dimethyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydrox y -6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthalenyl ester, [1S*-[1a,3a,7b,8b(2S*,4S),-8ab]]. The empirical formula of simvastatin is C25H38O5 and its molecular weight is 418.57. Simvastatin is a white to off-white, nonhygroscopic, crystalline powder that is practically insoluble in water, and freely soluble in chloroform, methanol, and ethanol. Tablets Zocor for oral administration contain either 5 mg, 10 mg, 20 mg, 40 mg or 80 mg of simvastatin and the following inactive ingredients: cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, iron oxides, lactose, magnesium stearate, starch, talc, titanium dioxide, and other ingredients. Butylated hydroxyanisole is added as a preservative.

Response:

On 11/6/02 9:44 PM, in article dkly9.11929$6b.350…@news2.east.cox.net, "Al Knowles" <acknow…@cox.net> wrote: > It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, > who > could tell us right now if the lipitor has any affect on their MS > symptoms…

I am. Been on it for 8 days now and can see substantial improvements in all areas. I’m a primary progressive MS too. 80 mg a day is the dosage. I didn’t want to wait years for the government to finish testing it for MS’ers. Each day I notice a slight improvement from the previous one. Tone is reduced as is fatigue, more strength, less spasms, constipation not quite as bad. Transfers somewhat easier also. All symptoms are still present just not quite as strong as they were 8 days ago. Probably the most noticeable thing is the tremendous reduction in inflammation. All after only 8 days. I wonder where I’ll be after 8 months.

Response:

That’s great to hear. I have a couple questions: -How did you get the perscription? Did your doctor endorse this? -Are there any side effects? -What’s the cost like? Either way, keep us posted with how it’s going. -James K On Tue, 26 Nov 2002 21:36:35 -0600, Kearney Adams – Hide quoted text — Show quoted text -<kadams9…@myvine.com> wrote: >On 11/6/02 9:44 PM, in article dkly9.11929$6b.350…@news2.east.cox.net, "Al >Knowles" <acknow…@cox.net> wrote: >> It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, >> who >> could tell us right now if the lipitor has any affect on their MS >> symptoms… >I am. >Been on it for 8 days now and can see substantial improvements in all areas. >I’m a primary progressive MS too. 80 mg a day is the dosage. >I didn’t want to wait years for the government to finish testing it for >MS’ers. >Each day I notice a slight improvement from the previous one. >Tone is reduced as is fatigue, more strength, less spasms, constipation not >quite as bad. Transfers somewhat easier also. All symptoms are still present >just not quite as strong as they were 8 days ago. >Probably the most noticeable thing is the tremendous reduction in >inflammation. >All after only 8 days. >I wonder where I’ll be after 8 months.

[remove NOSPAM to reply by email]

Response:

On Tue, 26 Nov 2002 21:36:35 -0600, Kearney Adams <kadams9…@myvine.com> wrote in alt.support.mult-sclerosis: – Hide quoted text — Show quoted text ->On 11/6/02 9:44 PM, in article dkly9.11929$6b.350…@news2.east.cox.net, "Al >Knowles" <acknow…@cox.net> wrote: >> It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, >> who >> could tell us right now if the lipitor has any affect on their MS >> symptoms… >I am. >Been on it for 8 days now and can see substantial improvements in all areas. >I’m a primary progressive MS too. 80 mg a day is the dosage. >I didn’t want to wait years for the government to finish testing it for >MS’ers. >Each day I notice a slight improvement from the previous one. >Tone is reduced as is fatigue, more strength, less spasms, constipation not >quite as bad. Transfers somewhat easier also. All symptoms are still present >just not quite as strong as they were 8 days ago. >Probably the most noticeable thing is the tremendous reduction in >inflammation. >All after only 8 days. >I wonder where I’ll be after 8 months.

Are you keeping a diary?  Would you mind posting an update once a month? — "Make sure you send alot more porno .. My kid really enjoys it .."    - Tom Hennessy (ironjust…@aol.com) 2002-10-29 in alt.support.mult-sclerosis Message-ID: <[email protected]>

Response:

I’ve been taking Lipitor for  over a year, for cholesterol, and at that dosage I see NO affect on MS. Gaylan "Kearney Adams" <kadams9…@myvine.com> wrote in message

news:BA0999E3.6281%[email protected]… – Hide quoted text — Show quoted text -> On 11/6/02 9:44 PM, in article dkly9.11929$6b.350…@news2.east.cox.net, "Al > Knowles" <acknow…@cox.net> wrote: > > It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, > > who > > could tell us right now if the lipitor has any affect on their MS > > symptoms… > I am. > Been on it for 8 days now and can see substantial improvements in all areas. > I’m a primary progressive MS too. 80 mg a day is the dosage. > I didn’t want to wait years for the government to finish testing it for > MS’ers. > Each day I notice a slight improvement from the previous one. > Tone is reduced as is fatigue, more strength, less spasms, constipation not > quite as bad. Transfers somewhat easier also. All symptoms are still present > just not quite as strong as they were 8 days ago. > Probably the most noticeable thing is the tremendous reduction in > inflammation. > All after only 8 days. > I wonder where I’ll be after 8 months.

Response:

On 6 Nov 2002 15:35:01 -0800, dianekkomar…@msn.com (Diane Komaroff) wrote in alt.support.mult-sclerosis: – Hide quoted text — Show quoted text ->Did anybody just see CNN? >They had a report on the anti-colesterol drug, called Lipitor.   >They have seen positive results with iddy biddy mice; of course, they have had >to use ten times the amount used on a human for colesterol. >They found it has been excellent on the mice, and are planning on testing it on >us. >If it helps, they said it wouldn’t take as long with the danger testing >as it has already been passed here for colesterol >Soooooooooooooo??????????????? >Diane

I have been watching this for some time.  Here is an article from last April about one of the anti-cholesterol drugs, but if we were mice then we would have been cured long ago. =============================================================== A commonly used cholesterol lowering drug has been used to reverse the symptom of multiple sclerosis in lab experiments on mice. The statin drug atorvastatin is prescribed for patients at risk of heart disease because it reduces the levels of potentially harmful cholesterol in the blood. However, it also has the ability to influence the immune system. In lab tests it was effective at reversing paralysis in mice with MS-type symptoms. The research was carried out by a team from Stanford University in the US. MS is caused by the immune system turning in on itself and attacking the body’s own central nervous system. This results in the progressive destruction of myelin – the tissue that sheathes and protects the nerves. Without myelin, the nerves cease to function properly, and patients gradually lose the ability to move normally. Eventually they become paralysed. Related condition The researchers worked on mice which had a similar condition to MS. In this condition the myelin destruction is caused by specialised immune system cells called T lymphocytes. These cells produce too many cytokines – chemicals which inflame the nervous system and stimulate myelin damage. The researchers found that the statin drug significantly reduced inflammation. Not only did the drug reduce the secretion of cytokines that cause inflammation, it stimulated production of another type of cytokine that has the opposite effect. The researchers believe that statins may also be useful at treating other autoimmune diseases such as insulin-dependent diabetes and rheumatoid arthritis. ‘Encouraging’ Professor John Greenwood, of University College London, who is funded by the MS Society, said the drugs had been shown to have a multiple effect on the immune system. He has worked closely with scientists from the Institute of Ophthalmology. He told BBC News Online: "Interestingly, a study conducted by us using a different class of inhibitors, which are able to inhibit some of the same target molecules as statins, have also been shown to limit brain inflammation." Christine Jones, chief executive of the MS Trust, said: "Of course these are very early findings but it may be that this experimental work will prove useful in terms of therapy for MS. "Particularly encouraging, according to reported findings, is that this treatment, based on a cholesterol lowering agent, actually reverses symptoms." Professor Greenwood’s research is one of three studies into the how immune cells enter the brain and attack the myelin coating which are being funded by the MS Society. — From: watchman (watch…@nucleus.com) [Now ironjust...@aol.com] Newsgroups: alt.support.thyroid Date: 2002-01-12 15:56:30 PST "Look lady .. if you don’t know what you are talking about ‘medically’ .. then stay out of it .. The man has had three miscarriages/spontaneous abortions."

Response:

"Al Knowles" <acknow…@cox.net> wrote in message <news:dkly9.11929$[email protected]>… > It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, > who > could tell us right now if the lipitor has any affect on their MS > symptoms…

<snip> I have been taking lipitor for at least 5 years. I have not seen any effect on my MS symptoms. There is one factor, I was taking lipitor regularly when I was diagnosted. Sorry, I could not help. Seamus I am not Irish, I just play one at renaissance faires and drink their whiskey. Going to faire this weekend.

Response:

On 7 Nov 2002 07:20:11 -0800, ddeib…@onr.com (Seamus) wrote in alt.support.mult-sclerosis: >"Al Knowles" <acknow…@cox.net> wrote in message <news:dkly9.11929$[email protected]>… >> It’s hard to believe there isn’t some PwMS who isn’t also taking lipitor, >> who >> could tell us right now if the lipitor has any affect on their MS >> symptoms… ><snip> >I have been taking lipitor for at least 5 years. I have not seen any >effect on my MS symptoms. There is one factor, I was taking lipitor >regularly when I was diagnosted. Sorry, I could not help. >Seamus

The required dosage might be different.  <shrug> — From: doe (ironjust…@aol.comdoe) Newsgroup: Sci.med  Date: 2002-10-13 18:14:20 PST [snip] That would make you even more clueless than me .. or can’t you understand that

Response:

Did anybody just see CNN? They had a report on the anti-colesterol drug, called Lipitor.   They have seen positive results with iddy biddy mice; of course, they have had to use ten times the amount used on a human for colesterol. They found it has been excellent on the mice, and are planning on testing it on us. If it helps, they said it wouldn’t take as long with the danger testing as it has already been passed here for colesterol Soooooooooooooo??????????????? Diane

Response:

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